UVB radiation accelerates skin aging by increasing cellular oxidants, leading to senescence and excess production of MMP-1, which causes wrinkles and delays wound healing. Passion fruit seeds (PFS) are rich in piceatannol (PCT), known for its antioxidant and anti-aging properties.

This study examined the effects of PFS extract on UVB-exposed skin cells (HaCaT). The extract, rich in PCT, reduced cellular oxidants, decreased senescence, and lowered MMP-1 production at both protein and mRNA levels.

It also promoted wound healing by enhancing cell migration and increasing EGFR mRNA expression. Additionally, SIRT1 production, associated with cellular rejuvenation, was boosted.

In conclusion, PFS extract shows promise for skincare and wound healing by reducing skin aging effects and supporting tissue repair.