Artemisinin and its derivatives are among the front line drugs for malarial treatment due to their high efficacy and minimal side effects.  In addition and perhaps most importantly, artemisinins are also active against parasites that are resistant to other types of anti-malarial drugs.  Although the exact molecular basis of artemisinin-mediated toxicity remains unclear and despite the efforts to prevent the development of artemisinin resistance using combination therapies, many studies have shown that artemisinin resistance in malaria parasites has already emerged.  Our study aims to enhance the understanding of the basic molecular processes involved in the anti-malarial activity of artemisinin which can assist in the design of artemisinin based anti-malarial combination therapies to prevent the emergence of drug resistance as well as aid in the development of novel therapeutics against malaria.