Genetic Diseases: Mechanisms and Therapeutics
Research Topic
Discovering for novel therapeutic strategies
Our laboratory’s mission is to apply knowledge drawn from using a model system to understand the molecular mechanisms underlying human diseases. The ultimate goal is to search for novel therapeutic strategies that can improve human health and quality of life.
- Scopes of the research:
– Targeted therapies for genetic disorders
– Development of novel anti-cancer agents
– Anti-aging compounds and functional food for health
Amornrat Naranuntarat Jensen, PhD
Deputy Head of Department, Associate Professor
Pornthip Chaichompoo, Ph.D
Associate Professor
Research Topic
Thalassemia: From Clinic to Bench and Back Again
Thalassemia, characterized by defective globin synthesis, leads to severe anemia and various complication such as iron overload, oxidative stress, immune dysfunction, and cardiovasculopathy. We investigate the disease from molecular to clinical levles to uncover pathomechanisms, identify prognostic biomarkers, and develop theranostic strategies that bridge clinical needs with basic science.
- Scopes of the research:
– Investigating molecular to clinical pathomechanisms in thalassemia.
– Identifying novel biomarkers for prognosis and targeted therapy.
– Exploring iron metabolism, oxidative stress, extracellular vesicle biology, immune abnormalities, and immunothrombosis to understand systemic pathologies, such as cardiovascular disease and cognitive decline, in thalassemia.
– Applying omics technologies for disease mechanism discovery.
– Translating basic science into potential theranostics, such as “Novel hemoglobin F inducers as optional therapeutics in thalassemia”.