Research Topic
Discovering for novel therapeutic strategies
Our laboratory’s mission is to apply knowledge drawn from using a model system to understand the molecular mechanisms underlying human diseases. The ultimate goal is to search for novel therapeutic strategies that can improve human health and quality of life.
- Scopes of the research:
– Targeted therapies for genetic disorders
– Development of novel anti-cancer agents
– Anti-aging compounds and functional food for health
Amornrat Naranuntarat Jensen, Ph.D
Deputy Head of Department, Associate Professor
Nisamanee Charoenchon, Ph.D
Lecturer
Research Topic
Plant extracts and skin research
Premature skin aging, or photoaging, is primarily caused by prolonged ultraviolet (UV) radiation exposure. This process leads to the degradation of collagen and elastic fibers, resulting in wrinkles, as well as hyperpigmentation due to disrupted melanin distribution. In severe cases, photoaging can contribute to the development of skin cancer.
My research focuses on the histological and molecular alterations associated with skin aging, particularly in response to bioactive compounds and crude extracts from economically significant plant species. Using cellular and zebrafish models, I investigate their anti-aging and photoprotective effects, with additional emphasis on photobiological responses and toxicity evaluation.
- Scopes of the research:
– Skin aging
– Plant extraction and analysis
– Synthetic non-ionizing and UV irradiation
– Zebrafish model (histology and fish embryo toxicity test (FET))
Research Topic
The microbiome and its influence on aging
The gut microbiome undergoes significant changes throughout life, influenced by factors like diet, age, and health conditions. Alterations in the composition and function of these microbiomes can impact various aspects of aging, including health, inflammation, and metabolic processes. In humans, these changes can impact aging, with some studies suggesting a link between a healthy, diverse gut microbiome and resistance to age-related diseases and even longevity. In animals, similar trends are observed, highlighting the importance of the gut microbiome in overall health and aging.
- Scopes of the research:
– Bioinformatics and System biology
– High-throughput and high-dimensional data analysis; microbiome data analysis, next-generation sequencing data analysis and gene expression data analysis
– Biomarker identification
– Machine learning for biological data analysis
Miss Athisri Sitthipunya, Ph.D.
Scientist