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Assoc. Prof. Dr. Prasit Suwannalert

E-mail: prasit.suw@mahidol.ac.th, parasit109@yahoo.com

EDUCATION

  • Postdoctoral research, Kumamoto University, Japan
  • Ph.D. (Pathobiology), Mahidol University, Thailand
  • M.Sc. (Medical Biochemistry), Khon Kaen University, Thailand
  • B.Sc. (Medical Technology), Naresuan University, Thailand

RESEARCH TOPIC : Free radicals and pathological changes

RATIONAL AND RESEARCH METHODOLOGY : An imbalance between radicals and anti-radicals capacity has been proposed to play an important role in the progression of pathological changes. Oxidative stress is considered a major contributor to various pathologies including aging and cancers. The research is on the field of antioxidants and natural products prevent pathological changes of aging and cancers.

SCOPE OF RESEARCH :

  • Anti-oxidants of natural products
  • Oxidative stress and cancer
  • Anti-melanogenesis

AWARDS / ACTIVITIES

  • The 2010 Outstanding Alumni of Faculty of Allied Health Science, Naresuan University, Thailand
  • The 2014 Outstanding Alumni of Sarakhampittayakhom School, Mahasarakham, Thailand
  • Invited reviewer for
    1. Asian Pacific Journal of Cancer Prevention (APJCP)
    2. Tumor biology
    3. Cancer Biomarkers

PUBLICATION (FULL PAPER)

1. Prasit Suwannalert, Patcharee Boonsiri, Tueanjit Khampitak, Kovit Khampitak, Pote Sriboonlue, Puangrat Yongvanit. The levels of lycopene, alpha tocopherol and a marker of oxidative stress in healthy northeastern Thai elderly. Asia Pacific Journal of Clinical Nutrition 2007; 16(Suppl 1), 27-30.

 

2. Prasit Suwannalert*, Sirichet Rattanachitthawat, Chaiyavat Chaiyasut, Suda Riengrojpitak. High levels of 25-Hydroxyvitamin D3 [25(OH)D3] and α -tocopherol prevent oxidative stress in rats that consume Thai brown rice. Journal of Medicinal Plants Research 2010; 4(2), 120-124.

 

3. Sirichet Rattanachitthawat, Prasit Suwannalert*, Chaiyavat Chaiyasut, Suda Riengrojpitak, Somsak Pantuwatana. Phenolic content and antioxidant activities in red color of unpolished Thai rice prevent oxidative stress in rats. Journal of Medicinal Plants Research 2010; 4(9), 796-801.

 

4. Prasit Suwannalert*, Sirichet Rattanachitthawat. High levels of phytophenolics and antioxidant activities in Oryza sativa- unpolished Thai rice strain of Leum Phua. Tropical Journal of Pharmaceutical Research 2011; 10 (4), 431-436.

 

5. Prasit Suwannalert*, Nasapol Povichit, Pranom Puchadapirom, Mutita Junking. Anti-Aging Activity and Non-Toxic Dose of Phytooxyresveratrol from Artocarpus lakoocha Roxb. Tropical Journal of Pharmaceutical Research 2012; 11(1), 69-74.

 

6. Achiraya Tammasakchai, Sareeya Reungpatthanaphong, Chaiyavat Chaiyasut, Sirichet Rattanachitthawat, Prasit Suwannalert*. The red strain of Oryza sativa-unpolished Thai rice prevents oxidative stress and colorectal aberrant crypt foci (ACF) formation in rats. Asian Pacific Journal of Cancer Prevention 2012; 13, 1929-1933.

 

7. Sarawoot Palipoch, Chuchard Punsawad, Dutsadee Chinnapun, Prasit Suwannalert. Histopathology of Small Intestine Induced by Cisplatin in Male Wistar Rats. Walailak Journal of Science and Technology 2013; 10(6), 657-663.

 

8. Sarawoot Palipoch, Chuchard Punsawad, Dutsadee Chinnapun, Prasit Suwannalert. Amelioration of Cisplatin-Induced Nephrotoxicity in Rats by Curcumin and α -Tocopherol. Tropical Journal of Pharmaceutical Research 2013; 12(6), 973-979.

 

9. Adisak Palasap, Temduang Limpaiboon, Patcharee Boonsiri, Suthasinee Thapphasaraphong, Sakda Daduang, Prasit Suwannalert, Jureerat Daduang. The cytotoxic effect of phytophenolics from Caesalpinia mimosoides Lamk. on cervcal carcinoma cell lines through apoptotic pathway. Asian Pacific Journal of Cancer Prevention 2014; 15(1), 449-454.

 

10. Sarawoot Palipoch, Chuchard Punsawad, Phanit Koomhin, Prasit Suwannalert. Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress. BMC Complementary and Alternative Medicine 2014; 14:111.

 

11. Prasit Suwannalert, Ryusho Kariya, Ikuko Suzu, Seiji Okada. The Effects of Salacia reticulata on Anti-Cellular Oxidants and Melanogenesis Inhibition in α-MSH-stimulated and UV Irradiated B16 Melanoma Cells. Natural Product Communications 2014; 9(4), 551-554.

 

12. Jureerut Daduang, Adisak Palasap, Sakda Daduang, Patcharee Boonsiri, Prasit Suwannalert, Temduang Limpaiboon. Gallic acid enhancement of gold nanoparticle anticancer activity in cervical cancer cells. Asian Pacific Journal of Cancer Prevention 2015; 16(1), 169-174.

 

13. Pranom Puchadapirom, Wanwisa Himakhun, Patoomratana Tuchinda, Lakana Himakoun, Thidarat Koomsang, Prasit Suwannalert*. The Effects of Cleistanthoside A Tetraacetate Synthesis on Acute Toxicity and Bone Marrow Micronucleus in ICR Mice. Walailak Journal of Science and Technology 2015; 12(7), 605-611.

 

14. Noppawat Pengkumsri, Chaiyavat Chaiyasut, Chalermpong Saenjum, Sasithorn Sirilun, Sartjin Peerajan, Prasit Suwannalert, Sophon Sirisattha, Bhagavathi Sundaram Sivamaruthi. Physicochemical and antioxidative properties of black, brown and red rice varieties of northern Thailand. Food Science and Technology 2015; 35(2), 331-338.

 

15. Achiraya Tammasakchai, Chaiyavat Chaiyasut, Suda Riengrojpitak, Prasit Suwannalert*. Unpolished Thai rice prevents ACF formation and dysplastic progression in AOM-induced rats and induces apoptosis through redox alteration in CaCo-2 cells. Asian Pacific Journal of Cancer Prevention 2015; 16 (7), 2827-2832.

 

16. Noppawat Pengkumsri, Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Chalermpong Saenjum, Sasithorn Sirilun, Sartjin Peerajan, Prasit Suwannalert, Sophon Sirisattha, Khontaros Chaiyasut, Periyanaina Kesika. The influence of extraction methods on composition and antioxidant properties of rice bran oil. Food Science and Technology 2015; Jul-Sep; 35(3), 493-501.

 

17. Sasithorn Sirilun, Chaiyavat Chaiyasut, Noppawat Pengkumsri, Sartjin Peerajan, Khontaros Chaiyasut, Prasit Suwannalert, Bhagavathi Sundaram Sivamaruthi. Screening and characterization of ß-glucosidase production by Saccharomyces cerevisiae. Journal of Applied Pharmaceutical Science 2016; 6(5), 29-35.

 

18. Teerapat Rodboon, Pranom Puchadapirom, Seiji Okada, Prasit Suwannalert*. Oxyresveratrol from Artocarpus lakoocha Roxb. inhibit melanogenesis in B16 melanoma cells through the role of cellular oxidants. Walailak Journal of Science and Technology 2016; Apr; 13(4), 261-70.

 

19. Sareeya Reungpatthanaphong, Chaiyavat Chaiyasut, Sasithorn Sirilun, Prasit Suwannalert*. Unpolished Thai rice prevents aberrant crypt foci formation through the invovement of β-catenin and COX-2 expression in azoxymethane-treated rats. Asian Pacific Journal of Cancer Prevention 2016; 17(7):3 551-8.

 

20. Thanawat Pattananandecha, Sasithorn Sirilun, Yodsawee Duangjitcharoen, Bhagavathi Sundaram Sivamaruthi, Prasit Suwannalert, Sartjin Peerajan, Chaiyavat Chaiyasut. Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague–Dawley rats. Pharmaceutical Biology 2016; Sep; 54(9), 1596-605.

 

21. Sarawoot Palipoch, Phanit Koomhin, Chuchard Punsawad, Prasit Na-Ek, Apsorn Sattayakhom, Prasit Suwannalert. Heme oxygenase-1 alleviates alcoholic liver steatosis: histopathological study. Journal of Toxicologic Pathology 2016; 29(1), 7-15.

 

22. Prasit Suwannalert*, Witchuda Payuhakrit, Thidarat Koomsang. Anti-Oxidant, Pro-Oxidant and Anti-Inflammatory Effects of Unpolished Rice Relevant to Colorectal Cancer. Asian Pacific Journal of Cancer Prevention 2016; 17(12), 5047-56.

 

23. Noppawat Pengkumsri, Bhagavathi Sundaram Sivamaruthi, Sasithorn Sirilun, Prasit Suwannalert, Teerapat Rodboon, Chutinun Prasitpuriprecha, Sartjin Peerajan, Widawal Butrungrod, Chaiyavat Chaiyasut. Dietary supplementation of Thai black rice bran extract and yeast beta-glucan protects the dextran sodium sulphate mediated colitis induced rat. RSC Advances 2017; 7, 396-402.


24. Phanit Koomhin, Chuchard Punsawad, Prasit Suwannalert, Sarawoot Palipoch. Effect of a heme oxygenase-1 inducer on NADPH oxidase expression in alcohol-induced liver injury in male wistar rats. Tropical Journal of Pharmaceutical Research 2017; 16(5), 1039-44.

 

25. Chaiyavat Chaiyasut, Thanawat Pattananandecha, Sasithorn Sirilun, Prasit Suwannalert, Sartjin Peerajan, Bhagavathi Sundaram Sivamaruthi. Synbiotic preparation with lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci. Food Science and Technology 2017; 37(2), 328-36.

 

26. Parichaya Aimvijarn, Sarawoot Palipoch, Seiji Okada, Prasit Suwannalert*. Thai Water Lily extract induces B16 melanoma cell apoptosis and inhibits cellular invasion through the role of cellular oxidants. Asian Pacific Journal of Cancer Prevention 2018; 19(1), 149-153.

 

27. Parichaya Aimvijarn, Teerapat Rodboon, Witchuda Payuhakrit, Prasit Suwannalert*. Nymphaea pubescens induces apoptosis, suppresses cellular oxidants-related cell invasion in b16 melanoma cells. Pharmaceutical Sciences 2018; 24, 199-206.

 

28. Aladhraei M, Al-Salami E, Poungvarin N, Suwannalert P*. The roles of p53 and XPO1 on colorectal cancer progression in Yemeni patients. J Gastrointest Oncol 2019 Jun;10(3):437-44..

 

29. Palipoch S*, Koomhin P, Punsawad C, Suwannalert P. Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats. Trop J Pharm Res 2019 Apr;18(4):823-8.

 

30. Aladhraei M, Al-Thobhani AK, Poungvarin N, Suwannalert P*. Association of XPO1 overexpression with NF-κB and Ki67 in colorectal cancer. Asian Pac J Cancer Preven 2019;20(12):3747-54.

 

31. Aladhraei M, Al-Salami E, Poungvarin N, Suwannalert P*. The roles of p53 and XPO1 on colorectal cancer progression in Yemeni patients. J Gastrointest Oncol 2019 Jun;10(3):437-44.

 

32. Rodboon T, Palipoch S, Okada S, Charoenchon N, Nakornpakdee Y, Suwannalert P*. Oxyresveratrol inhibits cellular tyrosinase-related oxidative stress-induced melanogenesis in B16 melanoma cells. J Appl Pharm Sci 2020 Apr;10(4):8-13.

 

33. Rodboon T, Okada S, Suwannalert P*. Germinated riceberry rice enhanced protocatechuic acid and vanillic acid to suppress melanogenesis through cellular oxidant-related tyrosinase activity in B16 cells. Antioxidants 2020 Mar;9(3):247.

PRESENTATION

1. Pornnapat Chusangnin, Witchuda Payuhakrit, Achiraya Thammasakchai, Prasit Suwannalert. Unpolished Thai rice Induced Pro-Oxidants and Cellular Apoptosis in HT-29 Colorectal Cancer Cells. Mah Fah Luang University International Conference. Chaing rai, Thailand 2016 (p. 18-24) (Oral presentation).

2. Tharathip Muangthong, Witchuda Payuhakrit, Prasit Suwannalert. Unpolished Thai rice induce cancer cell toxicity and suppressed cellular oxidants-related to cancer cell migration in Caco-2 cells. Mah Fah Luang University International Conference. Chaing rai, Thailand 2016 (p.11-17). (Oral presentation).

3. Pitchaya Kornmai, Teerapat Rodboon, Prasit Suwannalert. The inhibitory effects of riceberry on cellular oxidants and melanogenesis in B16 melanoma cells. Mah Fah Luang University International Conference. Chaing rai, Thailand 2016 (p.1-7). (Oral presentation).

4. Achiraya Tammasakchai, Sareeya Reungpatthanaphong, Chaiyavat Chaiyasut, Suda Riengrojpitak, Prasit Suwannalert. The Effects of Unpolished Thai Rice on Aberrant Crypt Foci (ACF) Formation and Mucin Production in Azoxymethane (AOM)-Induced Colon Cancer. 7th Biennial Congress of ASEAN Society of Colorectal Surgeons, Singapore, Singapore 2014 (Oral Presentation).

5. Keerati Joyjamras, Sareeya Reungpatthanaphong, Achiraya Tammasakchai, Suda Riengrojpitak, Chaiyavat Chaiyasut, Prasit Suwannalert. High Phenolic Content of Unpolished Thai Rice Prevent Colorectal Aberrant Crypt Foci (ACF) Formation in Rats. 11th National Cancer Institute Conference, Bangkok, Thailand 2012 (Poster Presentation).

6. Achiraya Tammasakchai and Prasit Suwannalert. High Phenolics and Antioxidant Activity in Red Pigment Strain of Unpolished Thai Rice. 37th Congress of Science and Technology of Thailand, Bangkok, Thailand 2011 (Poster Presentation).

7. Prasit Suwannalert, Sirichet Rattanachitthawat, Chaiyavat Chaiyasut, Suda Riengrojpitak. Oxidative Stress Preventionin Rats Consume Thai Brown Rice. CHE-USDC Congress II. Pattaya, Thailand 2009 (Poster Presentation).

8. Prasit Suwannalert, Patcharee Boonsiri, Tueanjit Khampitak, Kovit Khampitak, Pote Sriboonlue, Puangrat Yongvanit, Maitree Suttajit. Tomato, lycopene may play an important balance role between oxidative stress and antioxidant capacity in Thais people. The International Free Radical Summer School 2006. Spetses Island, Greece 2006 (Poster Presentation).

9. Prasit Suwannalert, Chaiyavat Chaiyasut, Sunee Chansakaow. Free Radicals Scavenging Ability and Oxidative Protein Damage Protection of Medicinal Plants in Thailand.The 3rd International Conference on Oxidative Stress in Skin Medicine and Biology. Andros, Greece 2006 (Oral Presentation).

10. Prasit Suwannalert, Patcharee Boonsiri, Tueanjit Khampitak, Kovit Khampitak, Pote Sriboonlue, Puangrat Yongvanit. The Levels of Lycopene, Alpha-tocopherol and a Marker of Oxidative Stress in Healthy Northeast Thai Elderly. The joint 8th IUNS-International Symposium on Clinical Nutrition (8th ISCN) and 5th Asia-Pacific Clinical Nutrition Society (5th APCNS) Conference 2006, Hangzhou, China (Poster Presentation).

11. Prasit Suwannalert, Patcharee Boonsiri, Tueanjit Khampitak, Kovit Khampitak, Pote Sriboonlue, Puangrat Yongvanit. Serum Lycopene Level in Khon Kaen Healthy Elders. The 1st International Conference on Natural Products for Health and Beauty. Mahasarakham, Thailand. 2005 (Poster Presentation).

12. Prasit Suwannalert, Patcharee Boonsiri, Tueanjit Khampitak, Kovit Khampitak, Maitree Suttajit, Pote Sriboonlue, Puangrat Yongvanit. Tomatoes Intake Inversely Related to Cholesterol Levels in Northeastern Thai Elderly. The 11th Congress of Parenteral and Enteral Nutrition Society of Asia. Seoul, Korea. 2005 (Oral Presentation)