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Pornthip Chaichompoo, Ph.D

Associate Professor

E-mail: pornthip.chh@mahidol.ac.th

Tel: +66 02 201 5577, 5574

Education

2004

Bachelor of Science (Medical Technology) Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

2007

Master of Science (Immunology) Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

2010

Ph.D (Immunology) Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 

Research Topics & Interests

SCOPE OF RESEARCH

            Thalassemia is an inherited blood disorder that defects to globin synthesis and leads to abnormal hemoglobin production in red blood cells. Patients had anemia and other complications such as iron overload, cellular oxidative stress, heart failure, pulmonary hypertension, thrombosis and abnormal immunity. Although thalassemia was first discovered since 1925 by Prof. Cooley, the mechanisms of pathophysiology in thalassemic patients is still unclear that affects to prevention and cure. Researcher and team are investigating the mechanisms of pathophysiology in thalassemia, the effects of treatment on disease progressive and also biomarkers for disease severity and complications in thalassemia.

PERSONAL INFORMATION

POSITION TITLE : Associate Professor (Pathology)
                                LICENSURE INCLUDES: Medical Laboratory Scientists License, Thailand, 2004 (ท.น.6761)

 

RESEARCH INTEREST

1. Mechanism of hematopoietic cells and their extracellular vesicles on coagulation and inflammation in thalassemia.
2. Infection and immune cell function in thalassemia.
3. Effect of oxidative stress and iron status on anatomical pathology of thalassemic blood cells.
4. Biomarkers for disease severity and complications in thalassemia.
5. Discovery for novel hemoglobin F inducers from Thai medicinal plants, synthetic compounds and their analogs for b-thalassemia therapy.

Scopus Profile

Publication / Presentation

Publication

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research Grants

2011 – 2016

National Science and Technology Development Agency (NSTDA) under project entitle of “The pathophysiologic changes in thalassemia and novel therapy” (P-11-00435): “Role of miRNA in thalassemia disease severity”. (Co-investigator of subproject)

2013 – 2016

National Research Council of Thailand and The Japan Society for the Promotion of Sciences (NRCT-JSPS) Joint Research Program (ภค./2556-109): “Functional genomic approach for candidate gene intervention in the thalassemic iPS cells”. (Co-investigator)

2014 – 2015

Mahidol University Research Grant (TM15/2557): “Effects of platelet-derived microparticles on endothelial dysfunction in thalassemia”. (Principal investigator)

2015 – 2017

Office of the Higher Education Commission and Mahidol University under The National Research University Initiative (NRU): “The functions of leukocytes and related molecules in thalassemia”. (Principal investigator)

2014 – 2017

Faculty of Science, Mahidol University and The Thailand Research Fund (TRF) under project entitle of “Development Research Institute, Preclinic, Faculty of Science, Mahidol University” (IRG5780011): “A novel immunotherapy to ovarian and colon cancer”. (Co-investigator of subproject)

2015 – 2017

Faculty of Science, Mahidol University (ศธ 0517.091/ วจ1153): “Mechanism of microparticles on platelet and endothelial cell function in thalassemia”. (Principal investigator)

2016 – 2018

The Thailand Research Fund (TRF) (MRG5900843): “Mechanism of neutrophil function in thalassemia”. (Principal investigator)

2016 – 2018

Faculty of Science and Faculty of Medicine Ramathibodi Hospital, Mahidol University (SC-RA2559-2): “Ultrastructural changes of blood cells in thalassemia: a link with spleen function and iron deposite”. (Principal investigator)

2016 – 2019

The Thailand Research Fund (TRF) – Distinguished Research Professor Grant under project entitle of “Phenotypic and functional characteristics of immune cells that fail to protect host from infection” (DPG5980001): Phenotypic and molecular defects of neutrophils correlate with disease severity in thalassemia. (Co-investigator)

2017 – 2019

Faculty of Science, Mahidol University (ศธ 0517.091/ วจ340): “Effect of hydroxyurea on blood cell pathology in thalassemia”. (Principal investigator)

2019 – 2021

The Thailand Research Fund (TRF) (MRG6280230): “Iron overload induced neutrophil extracellular traps and neutrophil adhesion molecules contribute to thrombosis in thalassemia”. (Principal investigator)

2020 – 2021

National Research Council of Thailand 2019, Program Management Unit for Human Resources & Institutional Development, Research and Innovation under project entitle of “Pathophysiology and novel therapeutics in thalassemia” (B05F630062): “Mechanism of iron overload and oxidative stress on ineffective erythropoiesis in thalassemia”. (Co-investigator)

2020 – 2023

Multi-generation researchers, Research cluster, Mahidol University (MRC-MGR 01/2563): “Pathomechanism of blood cell damaged and complications in thalassemia”. (Co-investigator)

Academic Scholarships

June 2004 – May 2006 

Siriraj Graduate Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University, Thailand

June – September 2006   

Partial Thesis Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University, Thailand.

June 2007 – March 2010

The Royal Golden Jubilee Ph.D. Program, Thailand Research Fund, Thailand.

August 2010 

The Japan Society for the Promotion of Sciences (JSPS) Program

September 2010 – August 2011

The 1st Postdoctoral Mahidol University, Bangkok, Thailand Title “Telomere length and erythrocyte senescence in thalassemia”

October – December 2011   

Junior Research Fellowship Program 2011 (French Embassy)

October 2011 – June 2012       

Postdoctoral fellow at iMETI/CEA, Paris, France Title “Generation of hematopoietic stem cells from cynomolgus IPSCs” and “HumanBmi1 overexpression in human CD34 positive cells improve hematopoietic progenitor cell production and engraftment in NSG mice model”

July 2012 – June 2013 

The 2nd Postdoctoral Mahidol University, Bangkok, Thailand Title “Telomere length and erythrocyte senescence in thalassemia”

Work Experience

2006 – 2007       

Researcher, Division of Instruments for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

2010 – 2013 

Post-Doctoral Fellowship, Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand.

2011 – 2012

Post-Doctoral Fellowship under the Memorandum of Understanding between Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand and Laboratory of Gene and Cell therapy of the Institute of Emerging Diseases and Innovative Therapies (iMETI) (CEA-INSERM-university of paris 11), Paris, France.

2013 – 2017

Lecturer at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

2017 – 2020

Assistant Professor at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

2020 – Present

Associate Professor at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Professional Societies

2006

The Protein Society of Thailand

2010

The International Association of Providers of AIDS Care (IAPAC)

2012

European Society of Gene & Cell Therapy (ESGCT)

2015

The New York Academy of Sciences

Research Mentorship

Ms. Chayada Thiengtavor

Ms. Chayada Thiengtavor was supported under National Research Management System (NRMS) Year 2017, National Research Council of Thailand for M.Sc. thesis entitle “Mechanism of neutrophil function in thalassemia”.

Ms. Rattanawan Thubthed

Ms. Rattanawan Thubthed was supported under National Research Management System (NRMS) Year 2019, National Research Council of Thailand for M.Sc. thesis entitle “Neutrophil function on bacterial infection in thalassemia”.

Ms. Rattanawan Thubthed

Ms. Rattanawan Thubthed was supported under The Royal Golden Jubilee Ph.D. Program (RGJ) Year 2020, National Research Council of Thailand for Ph.D. thesis entitle “The mechanism of neutrophils on thrombosis in thalassemia”