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Assoc. Prof. Dr. Pornthip Chaichompoo
Email: pornthip.chh@mahidol.ac.th
Tel: 662-201-5577
SCOPE OF RESEARCH

            Thalassemia is an inherited blood disorder that defects to globin synthesis and leads to abnormal hemoglobin production in red blood cells. Patients had anemia and other complications such as iron overload, cellular oxidative stress, heart failure, pulmonary hypertension, thrombosis and abnormal immunity. Although thalassemia was first discovered since 1925 by Prof. Cooley, the mechanisms of pathophysiology in thalassemic patients is still unclear that affects to prevention and cure. Researcher and team are investigating the mechanisms of pathophysiology in thalassemia, the effects of treatment on disease progressive and also biomarkers for disease severity and complications in thalassemia.

PERSONAL INFORMATION

POSITION TITLE : Associate Professor (Pathology)
                                LICENSURE INCLUDES: Medical Laboratory Scientists License, Thailand, 2004 (ท.น.6761)

EDUCATION :
2004             Bachelor of Science (Medical Technology) Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
2007             Master of Science (Immunology) Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2010             Ph.D (Immunology) Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 

ACADEMIC SCHOLARSHIPS :

June 2004 – May 2006                      Siriraj Graduate Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University, Thailand

June – September 2006                    Partial Thesis Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University, Thailand.

June 2007- March 2010                    The Royal Golden Jubilee Ph.D. Program, Thailand Research Fund, Thailand.

August 2010                                       The Japan Society for the Promotion of Sciences (JSPS) Program

September 2010 – August 2011      The 1st Postdoctoral Mahidol University, Bangkok, Thailand Title “Telomere length and erythrocyte senescence in thalassemia”

October – December 2011              Junior Research Fellowship Program 2011 (French Embassy)

October 2011- June 2012                Postdoctoral fellow at iMETI/CEA, Paris, France Title “Generation of hematopoietic stem cells from cynomolgus IPSCs” and “HumanBmi1 overexpression in human CD34 positive cells improve hematopoietic progenitor cell production and engraftment in NSG mice model”

July 2012 – June 2013                       The 2nd Postdoctoral Mahidol University, Bangkok, Thailand Title “Telomere length and erythrocyte senescence in thalassemia”

POSITION

2006-2007          Researcher, Division of Instruments for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
2010-2013           Post-Doctoral Fellowship, Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University,
                              Salaya Campus, Nakhon Pathom, Thailand.
2011-2012            Post-Doctoral Fellowship under the Memorandum of Understanding between Thalassemia Research Center, Institute of Molecular                                        Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand and Laboratory of Gene and Cell therapy of the Institute of                                 Emerging Diseases and Innovative Therapies (iMETI) (CEA-INSERM-university of paris 11), Paris, France.
2013-2017            Lecturer at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
2017-2020           Assistant Professor at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
2020-Present     Associate Professor at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

PROFESSIONAL SOCIETIES

2006                   The Protein Society of Thailand
2010                   The International Association of Providers of AIDS Care (IAPAC)
2012                   European Society of Gene & Cell Therapy (ESGCT)
2015                  The New York Academy of Sciences

RESEARCH INTEREST

1. Mechanism of hematopoietic cells and their extracellular vesicles on coagulation and inflammation in thalassemia.
2. Infection and immune cell function in thalassemia.
3. Effect of oxidative stress and iron status on anatomical pathology of thalassemic blood cells.
4. Biomarkers for disease severity and complications in thalassemia.
5. Discovery for novel hemoglobin F inducers from Thai medicinal plants, synthetic compounds and their analogs for b-thalassemia therapy.

RESEARCH GRANT
  • 2011-2016 Co-investigator of subproject. National Science and Technology Development Agency (NSTDA) under project entitle of “The pathophysiologic changes in thalassemia and novel therapy” (P-11-00435): “Role of miRNA in thalassemia disease severity”.
  • 2013-2016 Co-investigator. National Research Council of Thailand and The Japan Society for the Promotion of Sciences (NRCT-JSPS) Joint Research Program (ภค./2556-109): “Functional genomic approach for candidate gene intervention in the thalassemic iPS cells”.
  • 2014-2015 Principal investigator. Mahidol University Research Grant (TM15/2557): “Effects of platelet-derived microparticles on endothelial dysfunction in thalassemia”.
  • 2015-2017 Principal investigator. Office of the Higher Education Commission and Mahidol University under The National Research University Initiative (NRU): “The functions of leukocytes and related molecules in thalassemia”.
  • 2014-2017 Co-investigator of subproject. Faculty of Science, Mahidol University and The Thailand Research Fund (TRF) under project entitle of “Development Research Institute, Preclinic, Faculty of Science, Mahidol University” (IRG5780011): “A novel immunotherapy to ovarian and colon cancer”.
  • 2015-2017 Principal investigator. Faculty of Science, Mahidol University (ศธ 0517.091/ วจ1153): “Mechanism of microparticles on platelet and endothelial cell function in thalassemia”.
  • 2016-2018 Principal investigator. The Thailand Research Fund (TRF) (MRG5900843): “Mechanism of neutrophil function in thalassemia”.
  • 2016-2018 Principal investigator. Faculty of Science and Faculty of Medicine Ramathibodi Hospital, Mahidol University (SC-RA2559-2): “Ultrastructural changes of blood cells in thalassemia: a link with spleen function and iron deposite”.
  • 2016-2019 Co-investigator. The Thailand Research Fund (TRF) – Distinguished Research Professor Grant under project entitle of “Phenotypic and functional characteristics of immune cells that fail to protect host from infection” (DPG5980001): Phenotypic and molecular defects of neutrophils correlate with disease severity in thalassemia.
  • 2017-2019 Principal investigator. Faculty of Science, Mahidol University (ศธ 0517.091/ วจ340): “Effect of hydroxyurea on blood cell pathology in thalassemia”.
  • 2019-2021 Principal investigator. The Thailand Research Fund (TRF) (MRG6280230): “Iron overload induced neutrophil extracellular traps and neutrophil adhesion molecules contribute to thrombosis in thalassemia”.
  • 2020-2021 Co-investigator. National Research Council of Thailand 2019, Program Management Unit for Human Resources & Institutional Development, Research and Innovation under project entitle of “Pathophysiology and novel therapeutics in thalassemia” (B05F630062): “Mechanism of iron overload and oxidative stress on ineffective erythropoiesis in thalassemia”.
  • 2020-2023 Co-investigator. Multi-generation researchers, Research cluster, Mahidol University (MRC-MGR 01/2563): “Pathomechanism of blood cell damaged and complications in thalassemia”.

 

RESEARCH MENTORSHIP

1. Ms. Chayada Thiengtavor was supported under National Research Management System (NRMS) Year 2017, National Research Council of Thailand for      M.Sc. thesis entitle “Mechanism of neutrophil function in thalassemia”.
2. Ms. Rattanawan Thubthed was supported under National Research Management System (NRMS) Year 2019, National Research Council of Thailand          for M.Sc. thesis entitle “Neutrophil function on bacterial infection in thalassemia”.
3. Ms. Rattanawan Thubthed was supported under The Royal Golden Jubilee Ph.D. Program (RGJ) Year 2020, National Research Council of Thailand for        Ph.D. thesis entitle “The mechanism of neutrophils on thrombosis in thalassemia”

INTERNATIONAL PUBLICATION

1. Pattanapanyasat K, Gonwong S, Chaichompoo P, Noulsri E, Lerdwana S, Sukapirom K, Siritanaratkul N, Fucharoen S. Activated platelet-derived microparticles in thalassaemia. Brit J Haematol. 2007 Feb;136(3):462-71. Impact Factor: 2007: 4.490, 5-Year Impact Factor: 2007: 3.733, Category: Hematology-Q1.

2. Chaichompoo P, Bostik P, Kobkitjaroen J, Stephenson S, Udompunturuk S, Pattanapanyasat K, Ansari AA. Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV infected rhesus macaques. Cell Immunol. 2010 Apr;263(2): 176-87. Indexed in WOS: Impact Factor: 2010: 2.575, 5-Year Impact Factor: 2010: 2.333, Category: Cell biology-Q3, Immunology-Q3.

3. Chaichompoo P, Kumya P, Khowawisetsut L, Chiangjong W, Chaiyarit S, Pongsakul N, Sirithanaratanakul N, Fucharoen S, Thongboonkerd V, Pattanapanyasat K. Characterizations and proteome analysis of platelet-free plasma-derived microparticles in β-thalassemia/haemoglobin E patients. J Proteomics. 2012 Dec;5(76):239-50. Indexed in WOS: Impact Factor: 2012: 4.088, 5-Year Impact Factor: 2012: 4.302, Category: Biochemical research methods-Q1.

4. Keawvichit R, Khowawisetsut L, Chaichompoo P, Polsrila K, Sukklad S, Sukapirom K, Khuhapinant A, Fucharoen S, Pattanapanyasat K. Platelet activation and platelet-leukocyte interaction β-thalassemia/haemoglobin E patients with marked nucleated erythrocytosis. Ann Hematol. 2012 Nov;91(11):1685-94. Indexed in WOS: Impact Factor: 2012: 2.866, 5-Year Impact Factor: 2012: 2.635, Category: Hematology-Q2

5. Chaichompoo P, Pattanapanyasat K, Winichagoon P, Fucharoen S, Svasti S. Accelerated telomere shortening in β-thalassemia/HbE patients. Blood Cells Mol Dis. 2015;55(2):173-179. Indexed in WOS: Impact Factor: 2015: 2.731, 5-Year Impact Factor: 2015: 2.495, Category: Hematology-Q2. Rank: 34/70.

6. Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, et al. Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice. Haematologica. 2015 Oct;100(10):e428-31. Indexed in WOS: Impact Factor: 2015: 6.671, 5-Year Impact Factor: 2015: 5.877, Category: Hematology-Q1, Rank: 4/70, Top 10% (JCR).

7. Klaihmon P, Phongpao K, Kheansaard W, Noulsri E, Khuhapinant A, Fucharoen S, Morales NP, Svasti S, Pattanapanyasat K, Chaichompoo P. Microparticles from splenectomized β-thalassemia/HbE patients play roles on procoagulant activities with thrombotic potential. Ann Hematol. 2017 Feb;96(2):189-198. Indexed in WOS: Impact Factor: 2016: 3.083, 5-Year Impact Factor: 2016: 2.868, Category: Hematology-Q2, Rank: 30/70.

8. Leecharoenkiat K, Tanaka Y, Harada Y, Chaichompoo P, Sarakul O, Abe Y, Smith DR, Fucharoen S, Svasti S, Umemura T. Plasma microRNA-451 as new hemolytic marker in β0-thalassemia/HbE disease. Mol Med Rep. 2017 Mar;15:2495-2502. Indexed in WOS: Impact Factor: 2016: 1.692, 5-Year Impact Factor: 2016: 1.718, Category: Medicine, research and experimental-Q3, Rank: 85/128.

9. Siwaponanan P, Siegers JY, Ghazali R, Ng T, McColl B, Thiengtavor C, Fucharoen S, Chaichompoo P, Svasti S, Wijburg OL, Vadolas J. Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients. Blood. 2017 Jun;129(23):3087-3099. Indexed in WOS: Impact Factor: 2016: 13.164, 5-Year Impact Factor: 2016: 10.891, Category: Hematology-Q1, Rank: 2/70, Top 10% (JCR)

10. Kheansaard W, Phongpao K, Paiboonsukwong K, Pattanapanyasat K, Chaichompoo P, Svasti S. Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction. Sci Rep. 2018 Aug 29;8(1):13033. Indexed in WOS: Impact Factor: 2017: 4.122, 5-Year Impact Factor: 2017: 4.609, Category: Multidisciplinary sciences-Q1, Rank: 12/64

11. Manakeng K, Prasertphol P, Phongpao K, Chuncharunee S, Tanyong D, Worawichawong S, Svasti S, Chaichompoo P. Elevated levels of platelet and red cell-derived extracellular vesicles in transfusion dependent β-thalassemia/HbE patients with pulmonary arterial hypertension. Ann Hematol. 2018 online doi: 10.1007/s00277-018-3518-z. Indexed in WOS: Impact Factor: 2017: 2.845, 5-Year Impact Factor: 2017: 2.789, Category: Hematology-Q2, Rank: 28/71

12. Chaichompoo P (corresponding author), Qillah A, Sirankapracha P, Kaewchuchuen J, Rimthong P, Paiboonsukwong K, Fucharoen S, Svasti S, Worawichawong S. Abnormal red blood cell morphological changes in thalassemia associated with iron overload and oxidative stress. J Clin Pathol. 2019 Aug;72(8):520-524. Indexed in WOS: Impact Factor: 2019: 2.460, 5-Year Impact Factor: 2019: 2.403, Category: Pathology-Q2, Rank: 30/78. Indexed in Scopus: SJR Impact Factor: 2019: 0.971, Category: Pathology and Forensic Medicine-Q1, Rank: 40/209.

13. Thiengtavor C, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P (corresponding author). Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration. Br J Haematol. 2020 Apr;189(1):187-198. Indexed in WOS: Impact Factor: 2019: 5.518, 5-Year Impact Factor: 2019: 5.287, Category: Hematology-Q1, Rank: 14/76. Indexed in Scopus: SJR Impact Factor: 2019: 1.844, Category: Hematology-Q1, Rank: 16/132.

14. Siriworadetkun S, Thubthed R, Thiengtavor C, Paiboonsukwong K, Khuhapinant A, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P (corresponding author). Elevated levels of circulating monocytic myeloid derived suppressor cells in splenectomised b-thalassaemia/HbE patients. Br J Haematol. 2020 Aug; 191, e70-e100. Indexed in WOS: Impact Factor: 2019: 5.518, 5-Year Impact Factor: 2019: 5.287, Category: Hematology-Q1, Rank: 14/76. Indexed in Scopus: SJR Impact Factor: 2019: 1.844, Category: Hematology-Q1, Rank: 16/132.