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Lect. Niwat Kangwanrangsan, Ph.D.
E-mail. niwat.kan@mahidol.edu
Tel. 02-201-5576
EDUCATION

2013

Doctor of Philosophy (Medical Sciences), Department of Molecular Parasitology,
Graduate School of Medicine, Ehime University, Ehime, Japan

2004

Master’s Degree of Science (Anatomy), Department of Anatomy, Faculty of Science,
Mahidol University, Bangkok, Thailand

1998

Bachelor’s Degree of Science (Biology), Department of Biology, Faculty of Science,
Mahidol University, Bangkok, Thailand

1994

Secondary School, Taweethapisek School, Bangkok-yai, Bangkok, Thailand

RESEARCH EXPERIENCES & INTERESTS

Cell and molecular biology of Plasmodium infection

– Biology of malaria parasite in transmission stages
– Malaria transmission-blocking vaccines and drugs development
– P. vivax liver stage development in humanized mouse model
– Study of Plasmodium gene function by genetic manipulation

RESEARCH SCHOLARSHIPS
  • “Additive effect of Brucea javanica extract to antimalarial drugs” Faculty of Medicine, Thammasat University (2019-2020; Co-investigator)
  • “FRG-KO huHep mouse model for P. vivax pre-erythrocytic intervention studies” Bill and Melinda Gates Foundation (2015-2018; subcontract no. MU-39005; Co-investigator)
  • “Humanized mouse models for efficacy of novel P. vivax pre-erythrocytic antigens” DoD, U.S. Army Med RAA (2015-2017; subcontract no. MU-29001; Co-investigator)
  • “Development of glycoconjugate vaccine candidate against tuberculosis based on synthetic arabinan and mannan derived from Mycobacterium tuberculosis”
  • National Vaccine Institute, Thailand (Public Organization), (2015-2016, 2018-2019; Coinvestigator) “Characterization of Plasmepsin in sexual stage of P. falciparum” Research Institute, Rangsit University (2011-2013; Co-investigator)
  • “Study of the crude extract from Siam weeds for anti-malarial activity” Government Budget, Suan Dusit Rajabhat University (2012-2013; PI)
SCIENTIFIC MEETING ATTENDED
  • 7-9 April 2019: Malaria Liver Stage Meeting 2019, Novartis Institute for Tropical Diseases, Emeryville, California, USA.
  • 4-7 September 2018 (Oral Presentation): The 17th Awaji International Forum on Infection and Immunity, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan
  • 8-9 March 2018: Malaria Liver Stage Meeting 2018, Amari Watergate Bangkok, Bangkok, Thailand.
  • 3-12 February 2016: Liver Stage Malaria Consortium Meeting 2016, Seattle, Washington, USA
  • 9-11 September 2015: TALAS International Symposium (The 9th TALAS Annual Training and Workshop) “Institutional Animal Care and Use Committee (IACUC) Training and Current Issues in Laboratory Animal Research” Koja Seeha Room, 5th Floor, Faculty of Veterinary Science, Mahidol University – Salaya Campus, Nakhon Pathom, Thailand
  • 27-29 April 2015: Malaria Culture Systems Consortium 2015 Annual Meeting, New York, USA
  • 2-6 November 2014: ASTMH 63rd Annual Meeting, New Orleans, Louisiana, USA.
  • 5-7 March 2014: Malaria Consortium 2014: Humanized mouse model for malaria TPP and malaria culture systems, Madrid, Spain.
  • 20-25 January 2013 (Poster Presentation): Keystone Symposia: Malaria, New Orleans, Louisiana, USA.
  • 26-28 November 2012: AFSN 4th Annual Meeting&Symposium: Forensic Sciences Community Networking, Rama Garden Hotel, Bangkok, Thailand.
  • 17-18 July 2011 (Oral Presentation): 80th Japanese Society of Parasitology Meeting, Tokyo, Japan.
  • 27-28 March 2009 (Oral Presentation): 78th Japanese Society of Parasitology Meeting, Tokyo, Japan.
  • 7-8 January 2009: 43rd U.S.-Japan Joint Conference on Parasitic Diseases, International Medical Center of Japan, Tokyo, Japan.
  • 7-11 September 2008: The 8th Awaji International Forum on Infection and Immunity, Awaji Island, Hyogo, Japan.
  • 28 September 2007: The 5th Matsuyama International Symposium on Cell-Free Sciences, ANA Hotel, Matsuyama, Ehime, Japan.
  • 6 October 2006: The 4th Matsuyama International Symposium on Cell-Free Science, ANA Hotel, Matsuyama, Ehime, Japan.
  • 9-13 November 2003: The 11th International Symposium of the World Association of Veterinary Laboratory Diagnosticians and OIE Seminar on Biotechnology, Sofitel Central Plaza, Bangkok, Thailand.
  • 19-23 February 2003: The 10th Annual Meeting of the Thailand Research Fund, Queen Sirikit National Convention Center, Bangkok, Thailand.
PUBLICATIONS

1. Sahaphong S, Linthong V, Wanichanon C, Riengrojpitak S, Kangwanrangsan N, Viyanant V,Upatham ES, Chansue N, Sobhon P. Morphofunctional study of the hemocytes of Haliotis asinina. 2001. J Shellfish Res; 20(2): 711-6


2. Jiraungkoorskul W, Sahaphong S, Sobhon P, Riengrojpitak S, Kangwanrangsan N. Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice. 2005. Parasitol Int; 54(3):177-83.


3. Jiraungkoorskul W, Sahaphong S, Tansatit T, Kangwanrangsan N, Pipatshukiat S. Eurytrema pancreaticum: the in vitro effect of praziquantel and triclabendazole on the adult fluke. 2005. Exp Parasitol; 111(3):172-7.


4. Jiraungkoorskul W, Sahaphong S, Sobhon P, Riengrojpitak S, Kangwanrangsan N. Schistosoma mekongi: the in vitro effect of praziquantel and artesunate on the adult fluke. 2006. Exp Parasitol; 113(1): 16-23


5. Pankao V, Sirisriro A, Grams R, Vichasri-Grams S, Meepool A, Kangwanrangsan N, Wanichanon C, Ardseungneon P, Viyanant V, Upatham ES, Sobhon P. Classification of the parenchymal cells in Fasciola gigantica based on ultrastructure and their expression of fatty acid binding proteins (FABPs). 2006. Vet Parasitol ; 142: 281-292.


6. Jiraungkoorskul W, Sahaphong S, Kangwanrangsan N. Toxicity of copper in Butterfish (Poronotus triacanthus): tissues accumulation and ultrastructural changes. 2007. EnvironToxicol; 22(1): 92-100.


7. Jiraungkoorskul W, Sahaphong S, Kangwanrangsan N, Zakaria S. The protective influence of ascorbic acid against the genotoxicity of waterborne lead exposure in Nile tilapia, Oreochromis niloticus (L). 2008. J Fish Biol. 73(2):355-366


8. VanBuskirk KM, O’Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB Jr, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG Jr, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH. Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. 2009. Proc Natl Acad Sci U S A; 106(31):13004-9.


9. Bullen HE, Charnaud SC, Kalanon M, Riglar DT, Dekiwadia C, Kangwanrangsan N, Torii M, Tsuboi T, Baum J, Ralph SA, Cowman AF, de Koning-Ward TF, Crabb BS, Gilson PR. Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). 2012. J Biol Chem; 9;287 (11):7871-84.


10. Senarat S, Kettratad J, Yenchum W, Poolprasert P, Kangwanrangsan N. Microscopic organization of the eye of Stoliczkae’s barb Puntius stoliczkanus (day, 1871). Kasetsart J. 2013 Vol.47(5):733-8


11. Kangwanrangsan N, Tachibana M, Jenwithisuk R, Tsuboi T, Riengrojpitak S, Torii M, Ishino T. A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes. 2013. Malar J; 12(1):129.


12. Senarat S, Kettratad J, Jiraungkoorskul W, Kangwanrangsan N. Structural classifications in the digestive tract of short mackerel, Rastrelliger brachysoma (Bleeker, 1865) from Upper Gulf of Thailand. Songklanakarin J Sci Technol 2015; 37(5): 561-567.


13. Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbauger M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Prachumsri J and Kappe SH. Plasmodium vivax liver stage development and hypnozoite persistence in human liver chimeric mice. 2015. Cell Host Microbe; 8;17(4):526-35.


14. Senarat S, Kettratad J, NaLampang P, Gettongsong T, Karnjanapak C, Palasai A, Kangwanrangsan N, Jiraungkoorskul W. Structural organization of the thyroid gland and interrenal tissue with reference to endocrine parenchyma in short mackerel, Rastrelliger brachysoma (Bleeker, 1851). Agricul Nat Resour. 2016; 50(1): 60-63.


15. Charoenphon N, Anandsongvit N, Kosai P, Sirisidthi K, Kangwanrangsan N, Jiraungkoorskul W.Brahmi (Bacopa monnieri): Up-to-date of memory boosting medicinal plant: A review. Indian J Agri Res. 2016 Vol.50(1):1-7. doi: 10.18805/ijare.v50i1.8582.


16. Leelayuwapan H, Kangwanrangsan N, Chawengkirttikul R, Ponpuak M, Charlermroj R, Boonyarattanakalin K, Ruchirawat S and Boonyarattanakalin S. Synthesis and immunological studies of the lipomannan backbone glycans found on the surface of Mycobacterium tuberculosis. J of Org Chem 2017. Vol.82:7190-9.


17. Arredondo SA, Swearingen KE, Martinson T, Steel R, Dankwa DA, Harupa A, Camargo N, Betz W, Vigdorovich V, Oliver BG, Kangwanrangsan N, Ishino T, Sather N, Mikolajczak S, Vaughan AM, Torii M, Moritz RL, Kappe SHI. The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes. Front Cell Infect Microbiol. 2018 Nov 27;8:413. doi: 10.3389/fcimb.2018.00413.


18. Gualdrón-López M, Flannery EL, Kangwanrangsan N, Chuenchob V, Fernandez-Orth D, Segui-Barber J, Royo F, Falcón-Pérez JM, Fernandez-Becerra C, Lacerda MVG, Kappe SHI, Sattabongkot J, Gonzalez JR, Mikolajczak SA, Del Portillo HA. Characterization of Plasmodium vivax Proteins in Plasma-Derived Exosomes from Malaria-Infected Liver-Chimeric Humanized Mice. Front Microbiol. 2018 Jun 25;9:1271. doi: 10.3389/fmicb.2018.01271.


19. Senarat S, Kettratad J, Jiraungkoorskul W, Plumley FG, Tongmit K, Poolprasert P, Kangwanrangsan N, Amano M, Shimizu A, Boonyoung P. Identification of sbGnRH-GTHs system and estrogen receptor α (ER α) immunoreactivities in the mature testicular tissue in Rastrelliger brachysoma (Bleeker, 1851). EurAsia J Biosci. 2018 Dec Vol.12(2):385-92.


20. Charoenphon N, Kangwanrangsan N, Jiraungkoorskul W. Artemia salina lethality and histopathological studies on Bacopa monnieri leaf extract. Indian J Anim Res. 2018 Apr Vol.52(4):610-4. doi: 10.18805/ijar.v0iOF.7606.


21. Bunthitsakda W, Leelayuwapan H, Paha J, Kangwanrangsan N, Chawengkirttikul R, Ponpuak M, Ruchirawat S, Boonyarattanakalin S. Controlled rapid synthesis and in vivo immunomodulatory effects of LM α(1,6)mannan with an amine linker. Carbohydr Polym. 2018 Sep 1;195:420-431. doi: 10.1016/j.carbpol.2018.04.045.


22. Bertschi NL, Voorberg-van der Wel A, Zeeman AM, Schuierer S, Nigsch F, Carbone W, Knehr J, Gupta DK, Hofman SO, van der Werff N, Nieuwenhuis I, Klooster E, Faber BW, Flannery EL, Mikolajczak SA, Chuenchob V, Shrestha B, Beibel M, Bouwmeester T, Kangwanrangsan N, Sattabongkot J, Diagana TT, Kocken CH, Roma G. Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy. Elife. 2018 Dec 27;7. pii: e41081. doi: 10.7554/eLife.41081.


23. Kachenton S, Jiraungkoorskul W, Kangwanrangsan N, Tansatit T. Cytotoxicity and histopathological analysis of titanium nanoparticles via Artemia salina. Environ Sci Pollut Res Int. 2019 May;26(15):14706-14711. doi: 10.1007/s11356-018-1856-y.


24. Jenwithisuk R, Kangwanrangsan N, Tachibana M, Thongkukiatkul A, Otsuki H, Sattabongkot J, Tsuboi T, Torii M, Ishino T. Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes. Malar J. 2018 Dec 13;17(1):466. doi: 10.1186/s12936-018-2617-6.


25. Senarat S, Kettratad J, Kangwanrangsan N, Jiraungkoorskul W, Plumley FG, Amano M, Shimizu A, Boonyoung P, Kaneko G. Immunoreactivities of estrogen receptor alpha in brain and ovary of the short mackerel Rastrelliger brachysoma (Bleeker, 1851). AsPac J Mol Biol Biotechnol. 2019 Jun Vol.27(3):50-63.


26. Senarat S, Kettratad J, Kangwanrangsan N, Jiraungkoorskul W, Amano M, Shimizu A, Plumley FG, Tipdomrongpong S. The sbGnRH-GTH system in the female short mackerel, Rastrelliger brachysoma (Bleeker, 1851), during breeding season: implications for low gamete production in captive broodstock. Fish Physiol Biochem. 2019 Feb;45(1):1-18. doi: 10.1007/s10695-018-0509-x.


27. Gupta DK, Dembele L, Voorberg-van der Wel A, Roma G, Yip A, Chuenchob V, Kangwanrangsan N, Ishino T, Vaughan AM, Kappe SH, Flannery EL, Sattabongkot J, Mikolajczak S, Bifani P, Kocken CH, Diagana TT. The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development. Elife. 2019 May 16;8. pii: e43362. doi: 10.7554/eLife.43362.


28. Schäfer C, Roobsoong W, Kangwanrangsan N, Bardelli M, Rawlinson TA, Dambrauskas N, Trakhimets O, Parthiban C, Goswami D, Reynolds LM, Kennedy SY, Flannery EL, Murphy SC, Sather N, Draper SJ, Sattabongkot J, Mikolajczak SA, Kappe SHI. A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection. iScience. 2020 August 23;8. doi: 10.1016/j.isci.2020.101381.