Category: SDGs

SDGs, SDGs-2023

การตรวจวินิจฉัยโรคอัลฟ่าธาลัสซีเมียด้วยเทคนิคการติดตามด้วยสีแกพลูพเมดิเอเทตไอโซเทอร์ มอลแอพพลิฟิเคชั่น

Goals 3
Ensure healthy lives and promote well-being for all at all ages

การตรวจวินิจฉัยโรคอัลฟ่าธาลัสซีเมีย ด้วยเทคนิค การติดตามด้วยสี แกพลูพเมดิเอเทต ไอโซเทอร์ มอลแอพพลิฟิเคชั่น

อัลฟ่าโรคเบต้าธาลัสซีเมีย เป็นโรคความผิดปกติของฮีโมโกลบิน สามารถถ่ายทอดทางพันธุกรรม คู่สมรสที่มียีนพาหะชนิดอัลฟ่าธาลัสซีเมีย 1 มีโอกาสมีบุตรธิดาที่เป็นภาวะทารกบวมน้ำจากฮีโมโกลบินบาร์ต ซึ่งเป็นโรคอัลฟ่าธาลัสซีเมียชนิดรุนแรง ผู้ป่วยไม่สามารถดำรงชีวิตอยู่ได้ และยังเป็นผลให้เกิดภาวะครรภ์เป็นพิษ มีโอกาสทำให้มารดาเสียชีวิตได้ การตรวจทางห้องปฏิบัติการประจำไม่สามารถระบุยีนพาหะที่ทำให้อาจมีบุตรธิดาที่เสี่ยงต่อภาวะทารกบวมน้ำจากฮีโมโกลบินบาร์ต ต้องอาศัยวิธีการจำเพาะซึ่งต้องมีผู้เชี่ยวชาญ เครื่องมือราคาแพง และยังต้องการเวลาประมาณ 1-2 สัปดาห์ในการตรวจวินิจฉัยโรค ซึ่งอาจไม่ทันต่อการให้คำปรึกษาขณะตั้งครรภ์

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SDGs, SDGs-2023

Folic Acid Attenuates MSG-Induced Teratogenicity during A 2-Month Pregnancy by Preventing Neural Crest Cell Destruction and Malformation in Chick Embryo Models

Goals 3
Ensure healthy lives and promote well-being for all at all ages

Folic Acid Attenuates MSG-Induced Teratogenicity during A 2-Month Pregnancy by Preventing Neural Crest Cell Destruction and Malformation in Chick Embryo Models

Birth defects are multifactorial diseases caused by genetics and environmental factors or both; therefore, these defects can occur during any stage of pregnancy, especially in the first three months, which is essential for embryonic development. Chick embryos are one of the most beneficial models for human developmental studies. Monosodium glutamate (MSG) is a monosodium salt of glutamic acid, widely used as a flavor enhancer. Neural crest cells (NCCs) are a transient group of embryonic cells that play an essential role in embryogenesis. The present study aimed to investigate the treatment effect of folic acid (FA) on MSG-induced teratogenicity, focusing on the toxicity and teratogenic effects on somatic and neural crest cells in the chick embryo model.

The finding showed that the MSG at 2 mg/kg of egg weight induced retardation, tissue malformation, craniofacial and heart defects. In contrast, the FA alleviated those adverse effects and reduced the MSG-induced NCCs destruction in the eyes, heart, stomach, and nerves. In conclusion, although MSG harms embryos, FA effectively diminished its teratogenicity in the chick embryo model. Therefore, further research will be conducted at the molecular level to understand the mechanisms of the pathological mitigation of FA treatment.

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SDGs, SDGs-2023

Formulation optimization of sterilized xanthones-loaded nanoemulgels and evaluation of their wound-healing activities

Goals 3
Ensure healthy lives and promote well-being for all at all ages

Formulation optimization of sterilized xanthones-loaded nanoemulgels and evaluation of their wound-healing activities

Xanthones (XTs) are a group of active compounds. Because of the poor solubility of XTs, large amounts of solubilizers and surfactants are needed for the formulations of XTs. Wound healing is a complex process associated with hemostasis, inflammation, proliferation, and remodeling must occur in the correct order and amount of time for a wound to heal correctly. Therefore, wound management by using products containing some active compounds possessing anti-infective and anti-inflammatory activities, such as XTs, should increase the wound healing rate and reduce the risks of chronic wounds.

The objectives of this study were thus to optimize formulations of XTs-loaded nanoemulgel (XTs-NE-G), to determine the effect of sterilization on their physicochemical properties, and to investigate in vitro and in vivo wound healing activities of sterilized XTs-NE-Gs. The results suggested that the optimal formulation was the A5-F3, which was the XTs-NE-G containing 5% w/w sodium alginate and 3% w/w Pluronic F127. The sterilized A5-F3 exhibited stimulating activity towards releasing the growth factors from the skin fibroblast cells. Furthermore, the sterilized A5-F3 could accelerate the wound-healing process in the mice. The sterilized A5-F3 could thus be accepted as a potential product for investigating its wound-healing activities in further clinical studies.

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SDGs, SDGs-2023

Riceberry Rice Germination and UVB Radiation Enhance Protocatechuic Acid and Vanillic Acid to Reduce Cellular Oxidative Stress and Suppress B16F10 Melanogenesis Relating to F-Actin Rearrangement

Goals 3
Ensure healthy lives and promote well-being for all at all ages

Riceberry Rice Germination and UVB Radiation Enhance Protocatechuic Acid and Vanillic Acid to Reduce Cellular Oxidative Stress and Suppress B16F10 Melanogenesis Relating to F-Actin Rearrangement

Ultraviolet type B (UVB) radiation plays an important role in hyperpigmentation disorder, which induces cellular oxidative stress and causes abnormal melanin production and secretion. The stress condition plays an essential role in actin polymerization relating to F-actin rearrangement and forms dendrite to send melanin pigment to the uppermost layer of the skin.

Phenolic compounds are secondary metabolites that mainly synthesize under stress conditions to protect plants from harmful environments and have been reported as effective agents in anti-oxidant and anti-melanogenesis. This study provides knowledge that phytophenolic targets, protocatechuic acid, and vanillic acid in riceberry rice were enhanced through germination and UVB radiation processes. Riceberry rice’s modification showed high anti-oxidant and anti-tyrosinase properties together with the potential to reduce cellular oxidative stress and suppress B16F10 melanogenesis relating to F-actin rearrangement associated with dendrite formation.

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SDGs, SDGs-2023

Thioredoxin Reductase-1 as a Potential Biomarker in Fibroblast-Associated HCT116 Cancer Cell Progression and Dissemination in a Zebrafish Model

Goals 3
Ensure healthy lives and promote well-being for all at all ages

Thioredoxin Reductase-1 as a Potential Biomarker in Fibroblast-Associated HCT116 Cancer Cell Progression and Dissemination in a Zebrafish Model

The tumor microenvironment, especially that of fibroblasts-associated with epithelial-mesenchymal transition (EMT) process, strongly promotes colorectal cancer (CRC) progression including cancer migration, invasion, and metastasis.

This study provides knowledge that the high proliferation of fibroblast-associated pro-inflammatory cytokine secretions is linked to an increased ability to induce cellular oxidative stress and HCT116 cancer progression through the epithelial-mesenchymal transition (EMT) process. Fibroblast-cultured media (FCM) also caused cancer dissemination in the zebrafish model. Furthermore, thioredoxin reductase 1 (TrxR1)

expression was associated with FCM-inducing cancer progression. Thus, TrxR-1 is a potential biomarker to indicate fibroblast-associated colorectal cancer progression. TrxR-1 has been suggested as a biomarker candidate for colorectal cancer progression and prognostic evaluation in clinical applications.

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