Assoc. Prof. Dr. Amornrat Naranuntarat Jensen
Email: amornrat.nar@mahidol.edu
Tel: 662-201-5579
EDUCATION
2009 Ph.D. Toxicology Johns Hopkins University, Baltimore, Maryland, United States of America
2000 B.Sc. Pharmaceutical Sciences (First-class honors degree) Chulalongkorn University, Bangkok, Thailand
PROFESSIONAL EXPERIENCE
2016 – present Assistance Professor, Department of Pathobiology, Faculty of Science,
Mahidol University, Bangkok, Thailand
2009 – 2015 Lecturer, Department of Pathobiology, Faculty of Science,
Mahidol University, Bangkok, Thailand
2002 – 2009 Graduate Student
Johns Hopkins University, Department of Environmental Health Sciences,
Baltimore, Maryland, U. S. A.
2000-2002 Researcher
Pharmaceutical Organization of Thailand
Research and Development Institute, Bangkok, Thailand
HONORS
- Quinlan Kohn Scholarship awarded from 9th International Congress on Shwachman-Diamond Syndrome, USA (2018)
- Best Poster Presentation Award from Thailand Research Fund (TRF) (2014)
- Thesis Award from the National Research Council of Thailand (NRCT) (2012)
- Royal Thai Government Scholar in Biological Sciences (2002-2007)
PUBLICATIONS
1. Yang M, Cobine PA, Molik S, Naranuntarat A, Lill R, Winge DR, and Culotta VC. The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2 EMBO J. 2006;25, 1775-1783
(Q1 – Biochemistry and molecular biology, Impact factor 10.124)
2. Reddi AR, Jensen LT, Naranuntarat A, Rosenfeld L, Leung E, Shah R, and Culotta VC. The Overlapping Roles of Manganese and Cu/Zn SOD in Oxidative Stress Protection. Free Rad. Biol. Med. 2008;46, 154-162
(Q1 – Biochemistry and molecular biology, Impact factor 5.707)
3. Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, and Mootha VK. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metabolism. 2009;10, 119-30
(Q1 – Cell biology, Impact factor 5.328)
4. Naranuntarat, N, Jensen, LT, Pazicni S, Penner-Hahn, JE and Culotta VC. Interaction of mitochondrial iron with superoxide dismutase molecules. J. Biol. Chem. 2009;284, 22633-40
(Q1 – Biochemistry and molecular biology, Impact factor 18.207)
5. Jensen AN, Chindaudomsate W, Thitiananpakorn K, Mongkolsuk S, Jensen LT. Improper protein trafficking contributes to artemisinin sensitivity in cells lacking the KDAC Rpd3p. FEBS Lett. 2014;588(21):4018-25.
(Q1 – Biochemistry, Impact factor 3.341)
6. Kanprasoet W, Jensen LT, Sriprach S, Thitiananpakorn K, Rattanapornsompong K, Jensen AN*. Deletion of Mitochondrial Porin Alleviates Stress Sensitivity in the Yeast Model of Shwachman-Diamond Syndrome. J Genet Genomics. 2015;42(12):671-84.
(Q1 – Genetics, Impact factor 3.585)
7. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016;12(7):e1005763.
(Q1 – Genetics, Impact factor 7.758)
8. Aung HM, Huangteerakul C, Panvongsa W, Jensen AN, Chairoungdua A, Sukrong S, et al. Interrogation of ethnomedicinal plants for synthetic lethality effects in combination with deficiency in the DNA repair endonuclease RAD1 using a yeast cell-based assay. J Ethnopharmacol. 2018;223:10-21. (Q1 – Integrative & Complementary Medicine, Impact factor 3.414)
9. Jensen LT, Phyu T, Jain A, Kaewwanna C, Jensen AN*. Decreased accumulation of superoxide dismutase 2 within mitochondria in the yeast model of Shwachman-Diamond syndrome. J Cell Biochem. 2019;120(8):13867-80.
(Q2- Biochemistry & Molecular Biology, Impact factor 4.237)
10. Pongwattanakewin O, Phyu T, Suesattayapirom S, Jensen LT, Jensen AN*. Possible Role of the Ca(2+)/Mn(2+) P-Type ATPase Pmr1p on Artemisinin Toxicity through an Induction of Intracellular Oxidative Stress. Molecules. 2019;24(7).
(Q1 – Pharmaceutical Science, Impact factor 3.267)
11. Chalermwat C, Thosapornvichai T, Wongkittichote P, Phillips JD, Cox JE, N. Jensen AN, et al. Over-expression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. FEMS Yeast Research. 2019;19(8). pii: foz078. doi: 10.1093/femsyr/foz078. (Q1 – Applied Microbiology and Biotechnology, Impact factor 3.193)
12. Jain A, Nilatawong P, Mamak N, Jensen LT, Jensen AN*. Disruption in iron homeostasis and impaired activity of iron-sulfur cluster containing proteins in the yeast model of Shwachman-Diamond syndrome. Cell Biosci. 2020; 10: 105.
(Q1-Biochemistry and Molecular Biology, Impact Factor 2019: 5.026)
Book Chapters
Jensen, A. N. and Jensen, L. T. (2015) Manganese transport, trafficking and function in invertebrates. Manganese in Health
and Disease. pp. 1-27, eds. Aschner, M. and Costa, L. G., Royal Society of Chemistry (RSC)
RESEARCH GRANTS
Principle Investigator
2020- present: New Discovery and Frontier Research Grant, Mahidol University
Identifying the causes and cellular impacts of iron overload and vacuolar fragmentation in the yeast model of Shwachman-Diamond syndrome
2019-present: Research Career Development from Thailand Research Fund (TRF)
Identification of human tankyrase 1 inhibitors as potential anti-cancer agents using
a humanized yeast cell-based bioassay
2015-2017: Research Grant for New Scholar from Thailand Research Fund (TRF)
Investigation of the roles of mitochondrion and ER to Golgi protein trafficking in the molecular mechanisms of artemisinin sensitivity
2015-2017: Research Grant from Faculty of Science, Mahidol University
Investigation of mechanisms underlying mitochondrial damage and potential therapeutic strategies using the yeast model of Shwachman-Diamond syndrome
2012-2014: Research Grant for New Scholar from Thailand Research Fund (TRF)
Investigation of Molecular Basis of Artemisinin Actions and Resistance
2011-2013: Research Grant for Junior Staff from Faculty of Science, Mahidol University
Investigation of the mechanisms causing increased stress sensitivity in yeast model of Shwachman-Diamond syndrome
2010-2011: Research Grant for Junior Staff from Mahidol University
Characterization of the gene for Shwachman-Diamond syndrome
PRESENTATIONS
Oral Presentations
1. 9th International Congress on Shwachman-Diamond Syndrome, Texas, USA (2018)
Decreased accumulation of superoxide dismutase 2 within mitochondria in the yeast model of Shwachman-Diamond syndrome
2. 8th International Congress on Shwachman-Diamond Syndrome, Verona, Italy (2016) Deletion of mitochondrial porin
alleviates stress sensitivity in the yeast model of Shwachman-Diamond syndrome
3. Mahidol University, Department of Microbiology, Faculty of Sciences, Bangkok, Thailand (2015) Yeast as a model for
studying human genetic disease and drug development
4. Chulalongkorn University, Department of Biochemistry, Faculty of Pharmaceutical Sciences, Bangkok, Thailand (2011)
Yeast as a model for studying human genetic disease: the case of Shwachman-Diamond syndrome
5. Gordon Graduate Research Seminar on Bioinorganic Chemistry: Ventura California, U.S.A (2008) Effect of differential
metal bioavailability on activity of superoxide dismutase enzymes
6. Johns Hopkins University Yeast Genetics Meeting, Baltimore, MD, U.S.A. (2008) Effect of mitochondrial iron on manganese
superoxide dismutase
7. Mahidol University, Department of Pathobiology, Bangkok, Thailand (2007) Mitochondrial iron overload and activity of
superoxide dismutase enzymes
Poster Presentations
1. TRF research annual meeting (2014), Chonburi, Thailand Improper protein trafficking contributes to artemisinin sensitivity in cells lacking the lysine deacetylase Rpd3p
2. FASEB Summer Research Conference: Trace Element Metabolism (2008), Snowmass, CO, U.S.A The role of the Fe-S cluster scaffold Isu in iron inactivation of Sod2p.
3. Gordon Research Conference: Cell Biology of Metals (2007), Newport, Rhode Island, U.S.A Effect of differential metal bioavailability on activity of superoxide dismutase enzymes.
4. Third International Friedreich’s Ataxia Scientific Conference (2006), Bethesda, Maryland, U.S.A Inactivation of manganese superoxide dismutase by mitochondrial iron: a new aspect of iron toxicity.
5. FASEB Summer Research Conference: Trace Element Metabolism (2006), Snowmass, CO, U.S.A Inactivation of manganese superoxide dismutase by mitochondrial iron: a new aspect of iron toxicity.
OTHER ACTIVITIES
2018-present Program Secretary for Master of Science and Doctor of Philosophy Programs in Pathobiology,
Faculty of Science, Mahidol University
2015-2017 Program Director for Master of Science Program in Pathobiology, Faculty of Science, Mahidol University
2011 Organizing Committee, 37th Congress of Science and Technology of Thailand, Bangkok, Thailand
2010-2012 Faculty Senate Committee, Faculty of Science, Mahidol University
2009-2012 Organizing Committee, MUSC Graduate Research Exposition, Faculty of Science, Mahidol University