ACADEMIC STAFF
 
 

 

 
  Asst. Prof. Dr. Pornthip  Chaichompoo
Department of Pathobiology,
Faculty of Science, Mahidol University
272 Rama VI Road, Phayathai
Ratchathewi, Bangkok 10400, THAILAND
Tel: 662-201-5577
Fax: 662-354-7158
Email: pornthip.chh@mahidol.ac.th
   
 
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Last Update : November 30, 2018
 
 


 
 
  SCOPE OF RESEARCH

Thalassemia is an inherited blood disorder that defects to globin synthesis and leads to abnormal hemoglobin production in red blood cells. Patients had anemia and other complications such as iron overload, cellular oxidative stress, heart failure, pulmonary hypertension, thrombosis and abnormal immunity. Although thalassemia was first discovered since 1925 by Prof. Cooley, the mechanisms of pathophysiology in thalassemic patients is still unclear that affects to prevention and cure. Researcher and team are investigating the mechanisms of pathophysiology in thalassemia, the effects of treatment on disease progressive and also biomarkers for disease severity and complications in thalassemia.

 
 
 

PERSONAL INFORMATION

 

POSITION TITLE :  Assistant Professor (Pathobiology)

LICENSURE INCLUDES:  Medical Laboratory Scientists License, Thailand, 2004 (ท.น.6761)

EDUCATION :

2004    Bachelor of Science (Medical Technology) Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

2007    Master of Science (Immunology) Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

2010    Ph.D (Immunology) Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

 

 
  ACADEMIC SCHOLARSHIPS :

June 2004 - May 2006

June - September 2006

June 2007- March 2010

August 2010

September 2010 - August 2011


October – December 2011

October 2011- June 2012



July 2012 - June 2013

Siriraj Graduate Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University, Thailand

Partial Thesis Scholarship, Faculty of Medicine Siriraj hospital, Mahidol University, Thailand.

The Royal Golden Jubilee Ph.D. Program, Thailand Research Fund, Thailand.

The Japan Society for the Promotion of Sciences (JSPS) Program

The 1st Postdoctoral Mahidol University, Bangkok, Thailand Title “Telomere length and erythrocyte
senescence in thalassemia”

Junior Research Fellowship Program 2011 (French Embassy)

Postdoctoral fellow at iMETI/CEA, Paris, France Title “Generation of hematopoietic stem cells from cynomolgus IPSCs” and “HumanBmi1 overexpression in human CD34 positive cells improve hematopoietic progenitor cell production and engraftment in NSG mice model”

The 2nd Postdoctoral Mahidol University, Bangkok, Thailand Title “Telomere length and erythrocyte senescence in thalassemia”
 
 
  POSITION :

2006-2007


2010-2013


2011-2012




2013-2017

2017-present    
Researcher, Division of Instruments for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Post-Doctoral Fellowship, Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University,
Salaya Campus, Nakhon Pathom, Thailand.

Post-Doctoral Fellowship under the Memorandum of Understanding between Thalassemia Research Center,
Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand and Laboratory of Gene and Cell therapy of the Institute of Emerging Diseases and Innovative Therapies (iMETI)
(CEA-INSERM-university of paris 11), Paris, France.

Lecturer at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Assistant Professor at Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
 
 
 

PROFESSIONAL SOCIETIES :

2006    The Protein Society of Thailand

2010    The International Association of Providers of AIDS Care (IAPAC)

2012    European Society of Gene & Cell Therapy (ESGCT)

2015    The New York Academy of Sciences
 
 
 

RESEARCH INTEREST :

  1. Mechanism of hematopoietic cells and their extracellular vesicles on coagulation and inflammation in thalassemia.

  2. Infection and immune cell function in thalassemia.

  3. Effect of oxidative stress and iron status on anatomical pathology of thalassemic blood cells.

  4. Biomarkers for disease severity and complications in thalassemia.

  5. Discovery for novel hemoglobin F inducers from Thai medicinal plants, synthetic compounds and their analogs for b-thalassemia therapy.
 
 
 

RESEARCH GRANT :


2011-2016 Co-investigator of subproject. National Science and Technology Development Agency (NSTDA) under project
entitle of “The pathophysiologic changes in thalassemia and novel therapy” (P-11-00435): “Role of miRNA in
thalassemia disease severity”.
   
2013-2016 Co-investigator. National Research Council of Thailand and The Japan Society for the Promotion of Sciences
(NRCT-JSPS) Joint Research Program (ภค./2556-109): “Functional genomic approach for candidate gene intervention in the thalassemic iPS cells”.
   
2014-2015 Principal investigator. Mahidol University Research Grant (TM15/2557): “Effects of platelet-derived microparticles on endothelial dysfunction in thalassemia”.
   
2015-2017 Principal investigator. Office of the Higher Education Commission and Mahidol University under The National Research University Initiative (NRU): “The functions of leukocytes and related molecules in thalassemia”.
   
2014-2017 Co-investigator of subproject. Faculty of Science, Mahidol University and The Thailand Research Fund (TRF) under project entitle of “Development Research Institute, Preclinic, Faculty of Science, Mahidol University” (IRG5780011): “A novel immunotherapy to ovarian and colon cancer”.
   
2015-2017 Principal investigator. Faculty of Science, Mahidol University (ศธ 0517.091/ วจ1153): “Mechanism of microparticles on platelet and endothelial cell function in thalassemia”.
   
2016-2018 Principal investigator. The Thailand Research Fund (TRF) (MRG5900843): “Mechanism of neutrophil function in thalassemia”.
   
2016-2018 Principal investigator. Faculty of Science and Faculty of Medicine Ramathibodi Hospital, Mahidol University (SC-RA2559-2): “Ultrastructural changes of blood cells in thalassemia: a link with spleen function and iron deposite”.
   
2016-2019 Co-investigator. The Thailand Research Fund (TRF) – Distinguished Research Professor Grant under project entitle of “Phenotypic and functional characteristics of immune cells that fail to protect host from infection” (DPG5980001): Phenotypic and molecular defects of neutrophils correlate with disease severity in thalassemia.
   
2017-2019 Principal investigator. Faculty of Science, Mahidol University (ศธ 0517.091/ วจ340): “Effect of hydroxyurea on blood cell pathology in thalassemia”.
 
 
 
INTERNATIONAL PUBLICATION :
  1. Pattanapanyasat K, Gonwong S, Chaichompoo P, Noulsri E, Lerdwana S, Sukapirom K, Siritanaratkul N, Fucharoen S.
    Activated platelet-derived microparticles in thalassaemia. Brit J Haematol. 2007 Feb;136(3):462-71. Impact Factor: 2007:
    4.490, 5-Year Impact Factor: 2007: 3.733, Category: Hematology-Q1.

  2. Chaichompoo P, Bostik P, Kobkitjaroen J, Stephenson S, Udompunturuk S, Pattanapanyasat K, Ansari AA. Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV infected rhesus macaques. Cell Immunol. 2010 Apr;263(2):
    176-87. Indexed in WOS: Impact Factor: 2010: 2.575, 5-Year Impact Factor: 2010: 2.333, Category: Cell biology-Q3, Immunology-Q3.

  3. Chaichompoo P, Kumya P, Khowawisetsut L, Chiangjong W, Chaiyarit S, Pongsakul N, Sirithanaratanakul N, Fucharoen S,
    Thongboonkerd V, Pattanapanyasat K. Characterizations and proteome analysis of platelet-free plasma-derived microparticles
    in β-thalassemia/haemoglobin E patients. J Proteomics. 2012 Dec;5(76):239-50. Indexed in WOS: Impact Factor: 2012: 4.088,
    5-Year Impact Factor: 2012: 4.302, Category: Biochemical research methods-Q1.

  4. Keawvichit R, Khowawisetsut L, Chaichompoo P, Polsrila K, Sukklad S, Sukapirom K, Khuhapinant A, Fucharoen S,
    Pattanapanyasat K. Platelet activation and platelet-leukocyte interaction β-thalassemia/haemoglobin E patients with marked
    nucleated erythrocytosis. Ann Hematol. 2012 Nov;91(11):1685-94. Indexed in WOS: Impact Factor: 2012: 2.866, 5-Year Impact Factor: 2012: 2.635, Category: Hematology-Q2.

  5. Chaichompoo P, Pattanapanyasat K, Winichagoon P, Fucharoen S, Svasti S. Accelerated telomere shortening in β-thalassemia/HbE patients. Blood Cells Mol Dis. 2015;55(2):173-179. Indexed in WOS: Impact Factor: 2015: 2.731, 5-Year Impact Factor: 2015: 2.495, Category: Hematology-Q2. Rank: 34/70.

  6. Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, et al. Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice. Haematologica. 2015 Oct;100(10):e428-31. Indexed in WOS: Impact Factor: 2015: 6.671, 5-Year Impact Factor: 2015: 5.877, Category: Hematology-Q1, Rank: 4/70, Top 10% (JCR).

  7. Klaihmon P, Phongpao K, Kheansaard W, Noulsri E, Khuhapinant A, Fucharoen S, Morales NP, Svasti S, Pattanapanyasat K,
    Chaichompoo P. Microparticles from splenectomized β-thalassemia/HbE patients play roles on procoagulant activities with
    thrombotic potential. Ann Hematol. 2017 Feb;96(2):189-198. Indexed in WOS: Impact Factor: 2016: 3.083, 5-Year Impact Factor:
    2016: 2.868, Category: Hematology-Q2, Rank: 30/70.

  8. Leecharoenkiat K, Tanaka Y, Harada Y, Chaichompoo P, Sarakul O, Abe Y, Smith DR, Fucharoen S, Svasti S, Umemura T. Plasma microRNA-451 as new hemolytic marker in β0-thalassemia/HbE disease. Mol Med Rep. 2017 Mar;15:2495-2502. Indexed in WOS:
    Impact Factor: 2016: 1.692, 5-Year Impact Factor: 2016: 1.718, Category: Medicine, research and experimental-Q3, Rank: 85/128.

  9. Siwaponanan P, Siegers JY, Ghazali R, Ng T, McColl B, Thiengtavor C, Fucharoen S, Chaichompoo P, Svasti S, Wijburg OL, Vadolas J. Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients. Blood. 2017 Jun;129(23):3087-3099. Indexed in WOS: Impact Factor: 2016: 13.164, 5-Year Impact Factor: 2016: 10.891, Category: Hematology-Q1, Rank: 2/70, Top 10% (JCR).

  10. Kheansaard W, Phongpao K, Paiboonsukwong K, Pattanapanyasat K, Chaichompoo P, Svasti S. Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction. Sci Rep. 2018 Aug 29;8(1):13033. Indexed in WOS: Impact Factor: 2017: 4.122, 5-Year
    Impact Factor: 2017: 4.609, Category: Multidisciplinary sciences-Q1, Rank: 12/64

  11. Manakeng K, Prasertphol P, Phongpao K, Chuncharunee S, Tanyong D, Worawichawong S, Svasti S, Chaichompoo P. Elevated levels
    of platelet and red cell-derived extracellular vesicles in transfusion dependent β-thalassemia/HbE patients with pulmonary arterial hypertension. Ann Hematol. 2018 online doi: 10.1007/s00277-018-3518-z. Indexed in WOS: Impact Factor: 2017: 2.845, 5-Year Impact Factor: 2017: 2.789, Category: Hematology-Q2, Rank: 28/71.
 
 
  NATIONAL PUBLICATION : NONE
 
 
  INTERNATIONAL PROCEEDING :

  1. Thiengtavor C, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Svasti S, Chaichompoo P. Impaired phagocytosis and oxidative burst activity of monocytes on Escherichia coli infection in thalassemia. Mae Fah Luang University international conference 2016 on “advances in medical and health sciences”, Mae Fah Luang University, Chiang Rai, Thailand. November 23-25, 2016.

  2. Thubthed R, Siriworadetkun S, Pattanapanyasat K, Svasti S, Chaichompoo P. Quantification of neutrophil extracellular traps using immunofluorescent assay. The 9th International Graduate Research Conference, The Empress International Convention Center, The Empress Hotel, Chiang Mai, Thailand. May 17-18, 2018.
 
 
 

NATIONAL PROCEEDING :

  1. Phongpao K, Kheansaard W, Madtookung M, Pattanapanyasat K, Fucharoen S, Chaichompoo P, Svasti S. Hyperactivation and hyperfunction platelets in β-thalassemia. The 15th Graduate Research Conference, Khon Kaen University, Khon Kaen, Thailand.
    March 28, 2014.

  2. Siriworadetkun S, Thiengtavorn C, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Chaichompoo P, Svasti S. Decreased CD11b
    and CXCR2 Expression in β-thalassemia/HbE Leukocytes. The National and International Graduate Research Conference 2017,
    Khon Kaen University, Khon Kaen, Thailand. March 10, 2017.

  3. Qillah A, Nrizp T, Sirankapracha P, Khampan P, Rimthong P, Paiboonsukwong K, Svasti S, Worawichawong S, Chaichompoo P.
    Developed scanning electron microscope technique for red blood cell morphological analysis. The National and International
    Graduate Research Conference 2017, Khon Kaen University, Khon Kaen, Thailand. March 10, 2017.

  4. Wassanatip Y, Chaichompoo P, Svasti S. Screening for novel hemoglobin F inducer compounds. The National and International
    Graduate Research Conference 2017, Khon Kaen University, Khon Kaen, Thailand. March 10, 2017.

  5. Manakeng K, Svasti S, Chaichompoo P, Tanyong D. Expression of miR126 in microparticles from beta thalassemia/HbE patients: a preliminary study. The 8th International Graduate Students Conference on Population and Public Health Sciences (IGSCPP), College
    of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand. July 25, 2017.
 
 
 

BOOK OF ABSTRACTS – INTERNATIONAL MEETING:

  1. Chaichompoo P, Bostik P, Kobkitjaroen J, Stephenson S, Udompunturuk S, Pattanapanyasat K, Ansari AA. Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV infected rhesus macaques. XVIII International AIDS conference, Vienna, Austria. July 18-23, 2010.

  2. Chaichompoo P, Svasti S, Fucharoen S. Oxidative stress and shorten lymphocyte telomere length in sever b-thalassemia/Hb E patients. The 1st Pan-Asian conference on haemoglobinopathies, the Royal Orchid Sheraton Hotel and Towers, Bangkok, Thailand.
    February 8-10, 2012.

  3. Chaichompoo P, Pattanapanyasat K, Winichagoon P, Fucharoen S, Svasti S. Telomere shortening in β-thalassemia/HbE patients with severe disease. 10th Asia Pacific Conference on Human Genetics, Crowne Plaza Hotel, Kuala Lumpur, Malaysia. December 5-8, 2012.

  4. Svasti S, Kheansaard W, Phongpao K, Morales NP, Fucharoen S, Pattanapanyasat K, Chaichompoo P. Thalassemia microparticles induced platelet activation. Thalassemia International Federation, the 2nd Pan-Asian Conference on haemoglobinopathies, Hanoi, Vietnam, September 26-27, 2015.

  5. Chaichompoo P, Kheansaard W, Phongpao K, Klaihmon P, Fucharoen S, Pattanapanyasat K, Svasti S. Microparticles Induced Hemostatic Changes in Thalassemia. Tenth Cooley’s Anemia Symposium, Chicago, Illinois, USA. October 18-22, 2015.

  6. Siriworadetkun S, Thiengtavor C, Thubthed R, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S,
    Chaichompoo P. Effect of hydroxyurea treatment on neutrophil maturation and function in β-thalassemia/HbE patients. The belt and road conference on thalassemia: advancing knowledge in thalassemia, Convention room, The Science & Technology Building, Guangxi Medical University, Nanning, Guangxi, the People's Republic of China. October 31 – November 2, 2018.

  7. Kheansaard W, Phongpao K, Paiboonsukwong K, Pattanapanyasat K, Chaichompoo P, Svasti S. Microparticles from β-thalassemia/HbE patients activate endothelial cell. The belt and road conference on thalassemia: advancing knowledge in thalassemia, Convention room, The Science & Technology Building, Guangxi Medical University, Nanning, Guangxi, the People's Republic of China.
    October 31 – November 2, 2018.
 
 
 

BOOK OF ABSTRACTS – NATIONAL MEETING:

  1. Chaichompoo P. Circulating microparticles in beta-thalassemia/HbE. System Biology and Thalassemia Research. Chiang Mai University, Chiang Mai, Thailand. August 24-25, 2006.

  2. Chaichompoo P. Activated platelet-derived microparticles in beta-thalassemia/HbE. Siriraj Graduate Research Conference (SiGRC). Siriraj Hospital, Bangkok, Thailand. March 2, 2007.

  3. Chaichompoo P and Pattanapanyasat K. Elevated levels of oxidative stress increase expression of phosphatidylserine in thalassemia red blood cells. Excellent medical practice with sufficiency economy. Royal Thai Navy Convention Centre, Bangkok, Thailand. March 5-9, 2007.

  4. Chaichompoo P, Bostik P, Pattanapanyasat K, Ansari AA. Study on multiple KIR gene polymorphisms of and their correlation with plasma viral load in SIV-infected rhesus macaques. RGJ-Ph.D. Congress XI “Research Towards Sustainability”, Jomtien Palm Beach Hotel and Resort, Pattaya, Chonburi, Thailand. April 1 – 3, 2010.

  5. Chaichompoo P, Bostik P, Kobkitjaroen J, Stephenson S, Udompunturuk S, Pattanapanyasat K, Ansari AA. Genetic variations of KIR gene associated with plasma viral load in SIV-infected rhesus macaques. Functional Diversity and Immunopathoge-nesis in HIV/SIV Infection, Walailak University, Nakhon Si Thammarat, Thailand. September 16-17, 2010.

  6. Chaichompoo P, Svasti S, Fucharoen S. Telomere erosion in patients with b-thalassemia/Hb E disease. The 17th Thalassemia conference in Thailand, Ramagarden Hotel, Vipavadee Rd., Bangkok, Thailand. September 7-9, 2011.

  7. Chaichompoo P, Kumya P, Chiangjong W, Chaiyarit S, Thongboonkerd V, Fucharoen S, Pattanapanyasat K. Circulating blood cells and their microparticles exhibit oxidative stress that causes hypercoagulable state in thalassemia. International Conference Oxidative Stress in Congenital and Acquired Hemolytic Anemia, Garden Cliff Resort and Spa, Pattaya, Thailand. March 22-23, 2012.

  8. Chaichompoo P, Pattanapanyasat K, Winichagoon P, Fucharoen S, Svasti S. Telomere shortening in severe β-thalassemia/HbE.
    The 19th National Thalassemia Conference: Management strategy of Prevention and Control of Thalassemia, Khumpoukum Hotel,
    Chiang Mai, Thailand. October 30-November 1, 2013.

  9. Phongpao K, Kheansaard W, Pattanapanyasat K, Fucharoen S, Winichagoon P, Chaichompoo P, Svasti S. Microparticles induced platelet activation in b-thalassemia. The 20th National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. December 17-19, 2014.

  10. Kheansaard W, Phongpao K, Pattanapanyasat K, Fucharoen S, Winichagoon P, Chaichompoo P, Svasti S. β-Thalassemic microparticles stimulate endothelial cell adhesion molecule expression. The 20th National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. December 17-19, 2014.

  11. Kheansaard W, Phongpao K, Klaihmon P, Fucharoen S, Pattanapanyasat K, Svasti S, Chaichompoo P. Microparticles and hypercoagulable state in β-thalassemia. The 21st National Thalassemia Conference, Pullman Khon Kaen Raja Orchid Hotel, Khon Kaen, Thailand. March 9-11, 2016.

  12. Thiengtavor C, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Svasti S, Chaichompoo P. Innate immunity to Escherichia coli infection in β-thalasse-mia/HbE. The 22nd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. July 6-7, 2017.

  13. Siriworadetkun S, Thiengtavor C, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Svasti S, Chaichompoo P. Effect of hydroxyurea on neutrophil function in β-thalasse-mia. The 22nd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. July 6-7, 2017.

  14. Wassanatip Y, Nuamsee K, Paiboonsukwong K, Fucharoen S, Suksamran A, Chaichompoo P, Svasti S. Screening for novel hemoglobin F inducer compounds. The 22nd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. July 6-7, 2017.

  15. Thiengtavor C, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Svasti S, Vadolas J, Pattanapanyasat K, Chaichompoo P. Innate immunity in β-thalassemia/HbE. TRF-OHEC Annual Congress 2018 (TOAC 2018), The Regent Cha Am Beach Resort, Cha-Am, Phetchaburi, Thailand. January 10-12, 2018.

  16. Siriworadetkun S, Thiengtavor C, Thubthed R, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P. Hydroxyurea treatment cause abnormal PU.1 and C/EBP-β expression in β-thalassemia/HbE patients. The 23rd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. September 4-6, 2018.

  17. Wassanatip Y, Nuamsee K, Paioonsukwong K, Fucharoen S, Suksamran A, Chaichompoo P, Svasti S. Quercetin induce HbF production via Nrf2/Keap1 signaling pathway. The 23rd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. September 4-6, 2018.

  18. Thubthed R, Siriworadetkun S, Paiboonsukwong K, Fucharoen S, Pattanapanyasat K, Vadolas J, Svasti S, Chaichompoo P. Neutrophil extracellular trap in β-thalassemia. The 23rd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. September 4-6, 2018.

  19. Kheansaard W, Phongpao K, Paiboonsukwong K, Chaichompoo P, Svasti S. Microparticles from β-thalassemia/HbE patients induce endothelial cell activation and monocyte-endothelial cell adhesion. The 23rd National Thalassemia Conference, Miracle Grand Convention Hotel, Bangkok, Thailand. September 4-6, 2018.
 
 
 
 
 
 
Department of Pathobiology, Faculty of Science, Mahidol University,
  Rama VI Road, Bangkok 10400, Thailand.
  Phone : (662) 201-5550, 354-7158  Fax : (662) 354-7158 
Webmaster : athisri.sit@mahidol.ac.th